ALPK2 - Coexpedia

Co-expressed
Genes

GeneSet Analysis
GO-BP

GeneSet Analysis
DO

* Co-expressed genes with ALPK2 are ranked by sum of their edges' LLS score.

Rank	Gene Symbol and Name	Score
1	PAPPA pregnancy-associated plasma protein A, pappalysin 1	4.719
2	ITGA11 integrin subunit alpha 11	3.533
3	RAB31 RAB31, member RAS oncogene family	2.818
4	SNX20 sorting nexin 20	2.538
5	UBE2QL1 ubiquitin conjugating enzyme E2Q family-like 1	2.493
6	TNNI1 troponin I type 1 (skeletal, slow)	2.464
7	MYOM3 myomesin 3	2.434
8	CD36 CD36 molecule (thrombospondin receptor)	2.322
9	IL17D interleukin 17D	2.294
10	NDUFB3 NADH:ubiquinone oxidoreductase subunit B3	2.266
11	ADAM12 ADAM metallopeptidase domain 12	2.244
12	TPM3 tropomyosin 3	2.227
13	FCAMR Fc receptor, IgA, IgM, high affinity	2.177
14	GLIPR1 GLI pathogenesis-related 1	2.135
15	ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	2.094
16	SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2	2.087
17	MYH7 myosin, heavy chain 7, cardiac muscle, beta	2.029
18	HIVEP2 human immunodeficiency virus type I enhancer binding protein 2	2.020
19	SNAP91 synaptosome associated protein 91kDa	1.993
20	TMEM47 transmembrane protein 47	1.980
21	MXRA5 matrix-remodelling associated 5	1.955
22	FRMD6 FERM domain containing 6	1.947
23	TNNT1 troponin T type 1 (skeletal, slow)	1.880
24	ANKRD29 ankyrin repeat domain 29	1.877
25	INHBA inhibin beta A	1.851
26	SYNC syncoilin, intermediate filament protein	1.822
27	SMAD9 SMAD family member 9	1.822
28	TECRL trans-2,3-enoyl-CoA reductase-like	1.806
29	MYL3 myosin light chain 3	1.786
30	PRRX1 paired related homeobox 1	1.627
31	TWIST2 twist family bHLH transcription factor 2	1.627
32	PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme	1.621
33	NRG1 neuregulin 1	1.608
34	PCOLCE2 procollagen C-endopeptidase enhancer 2	1.570
35	MYH7B myosin, heavy chain 7B, cardiac muscle, beta	1.567
36	HTRA1 HtrA serine peptidase 1	1.537
37	C1QTNF3 C1q and tumor necrosis factor related protein 3	1.532
38	WIPF1 WAS/WASL interacting protein family member 1	1.520
39	PXDC1 PX domain containing 1	1.490
40	COL6A2 collagen, type VI, alpha 2	1.478
41	PAM peptidylglycine alpha-amidating monooxygenase	1.456
42	SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	1.434
43	GADD45B growth arrest and DNA damage inducible beta	1.413
44	TP53BP2 tumor protein p53 binding protein 2	1.404
45	GDF15 growth differentiation factor 15	1.403
46	TWIST1 twist family bHLH transcription factor 1	1.401
47	CDH2 cadherin 2, type 1, N-cadherin (neuronal)	1.400
48	CHN1 chimerin 1	1.376
49	IGFBP3 insulin like growth factor binding protein 3	1.357
50	TOM1L1 target of myb1 like 1 membrane trafficking protein	1.340
51	EFNB2 ephrin-B2	1.332
52	PTPRM protein tyrosine phosphatase, receptor type, M	1.271
53	CFAP43 cilia and flagella associated protein 43	1.227
54	S1PR3 sphingosine-1-phosphate receptor 3	1.223
55	IDI2 isopentenyl-diphosphate delta isomerase 2	1.208
56	TMEM119 transmembrane protein 119	1.173
57	PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1	1.172
58	POU3F3 POU class 3 homeobox 3	1.116
59	LOXL2 lysyl oxidase like 2	1.100
60	COL5A1 collagen, type V, alpha 1	1.087
61	PDLIM1 PDZ and LIM domain 1	1.019

Rank	GO Acc. and Desc.	p-value
1	GO:0030049 muscle filament sliding	1.155e-7
2	GO:0007155 cell adhesion	1.073e-5
3	GO:0002026 regulation of the force of heart contraction	1.063e-4
4	GO:0030199 collagen fibril organization	4.734e-4
5	GO:0055010 ventricular cardiac muscle tissue morphogenesis	5.773e-4
6	GO:0045668 negative regulation of osteoblast differentiation	6.913e-4
7	GO:0003009 skeletal muscle contraction	8.153e-4
8	GO:0045786 negative regulation of cell cycle	3.057e-3
9	GO:0046490 isopentenyl diphosphate metabolic process	3.297e-3
9	GO:0045932 negative regulation of muscle contraction	3.297e-3
9	GO:0046880 regulation of follicle-stimulating hormone secretion	3.297e-3
9	GO:0043624 cellular protein complex disassembly	3.297e-3
9	GO:0045112 integrin biosynthetic process	3.297e-3
9	GO:0042701 progesterone secretion	3.297e-3
9	GO:1903141 negative regulation of establishment of endothelial barrier	3.297e-3
9	GO:0097154 GABAergic neuron differentiation	3.297e-3
9	GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum	3.297e-3
9	GO:2000793 cell proliferation involved in heart valve development	3.297e-3
9	GO:0055012 ventricular cardiac muscle cell differentiation	3.297e-3
9	GO:0070165 positive regulation of adiponectin secretion	3.297e-3
9	GO:0060956 endocardial cell differentiation	3.297e-3
9	GO:0060379 cardiac muscle cell myoblast differentiation	3.297e-3
9	GO:0001519 peptide amidation	3.297e-3
9	GO:0003222 ventricular trabecula myocardium morphogenesis	3.297e-3
9	GO:0031449 regulation of slow-twitch skeletal muscle fiber contraction	3.297e-3
9	GO:0021773 striatal medium spiny neuron differentiation	3.297e-3
9	GO:0014728 regulation of the force of skeletal muscle contraction	3.297e-3
28	GO:0060048 cardiac muscle contraction	3.561e-3
29	GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	4.102e-3
30	GO:0038065 collagen-activated signaling pathway	6.584e-3
30	GO:0042541 hemoglobin biosynthetic process	6.584e-3
30	GO:1903225 negative regulation of endodermal cell differentiation	6.584e-3
30	GO:2000278 regulation of DNA biosynthetic process	6.584e-3
30	GO:0048711 positive regulation of astrocyte differentiation	6.584e-3
30	GO:0061029 eyelid development in camera-type eye	6.584e-3
30	GO:0060900 embryonic camera-type eye formation	6.584e-3
30	GO:0060363 cranial suture morphogenesis	6.584e-3
30	GO:0060045 positive regulation of cardiac muscle cell proliferation	6.584e-3
30	GO:0035356 cellular triglyceride homeostasis	6.584e-3
30	GO:0031290 retinal ganglion cell axon guidance	6.584e-3
30	GO:0033128 negative regulation of histone phosphorylation	6.584e-3
30	GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration	6.584e-3
30	GO:0010667 negative regulation of cardiac muscle cell apoptotic process	6.584e-3
30	GO:0014032 neural crest cell development	6.584e-3
30	GO:0018277 protein deamination	6.584e-3
46	GO:0030198 extracellular matrix organization	8.892e-3
47	GO:0046688 response to copper ion	9.860e-3
47	GO:0046881 positive regulation of follicle-stimulating hormone secretion	9.860e-3
47	GO:0042473 outer ear morphogenesis	9.860e-3
47	GO:0045077 negative regulation of interferon-gamma biosynthetic process	9.860e-3
47	GO:0045578 negative regulation of B cell differentiation	9.860e-3
47	GO:0070779 D-aspartate import	9.860e-3
47	GO:0051938 L-glutamate import	9.860e-3
47	GO:0051048 negative regulation of secretion	9.860e-3
47	GO:0048592 eye morphogenesis	9.860e-3
47	GO:0070296 sarcoplasmic reticulum calcium ion transport	9.860e-3
47	GO:0006929 substrate-dependent cell migration	9.860e-3
47	GO:0003180 aortic valve morphogenesis	9.860e-3
47	GO:0010842 retina layer formation	9.860e-3
47	GO:0019915 lipid storage	9.860e-3
61	GO:0042493 response to drug	1.276e-2
62	GO:0045721 negative regulation of gluconeogenesis	1.313e-2
62	GO:0038127 ERBB signaling pathway	1.313e-2
62	GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway	1.313e-2
62	GO:0043496 regulation of protein homodimerization activity	1.313e-2
62	GO:0045650 negative regulation of macrophage differentiation	1.313e-2
62	GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	1.313e-2
62	GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	1.313e-2
62	GO:1900165 negative regulation of interleukin-6 secretion	1.313e-2
62	GO:0086036 regulation of cardiac muscle cell membrane potential	1.313e-2
62	GO:0071726 cellular response to diacyl bacterial lipopeptide	1.313e-2
62	GO:0071639 positive regulation of monocyte chemotactic protein-1 production	1.313e-2
62	GO:0071638 negative regulation of monocyte chemotactic protein-1 production	1.313e-2
62	GO:0050920 regulation of chemotaxis	1.313e-2
62	GO:0048701 embryonic cranial skeleton morphogenesis	1.313e-2
62	GO:0070208 protein heterotrimerization	1.313e-2
62	GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity	1.313e-2
62	GO:0030879 mammary gland development	1.313e-2
62	GO:0030500 regulation of bone mineralization	1.313e-2
62	GO:0033690 positive regulation of osteoblast proliferation	1.313e-2
62	GO:0032964 collagen biosynthetic process	1.313e-2
62	GO:0010757 negative regulation of plasminogen activation	1.313e-2
62	GO:0019934 cGMP-mediated signaling	1.313e-2
84	GO:0030574 collagen catabolic process	1.324e-2
85	GO:0044539 long-chain fatty acid import	1.638e-2
85	GO:0090382 phagosome maturation	1.638e-2
85	GO:2000780 negative regulation of double-strand break repair	1.638e-2
85	GO:2000369 regulation of clathrin-mediated endocytosis	1.638e-2
85	GO:0050863 regulation of T cell activation	1.638e-2
85	GO:0007520 myoblast fusion	1.638e-2
85	GO:0001541 ovarian follicle development	1.638e-2
85	GO:0001942 hair follicle development	1.638e-2
85	GO:0035313 wound healing, spreading of epidermal cells	1.638e-2
85	GO:0034383 low-density lipoprotein particle clearance	1.638e-2
85	GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling	1.638e-2
85	GO:0016570 histone modification	1.638e-2
85	GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling	1.638e-2
98	GO:0045839 negative regulation of mitotic nuclear division	1.962e-2
98	GO:0042953 lipoprotein transport	1.962e-2
98	GO:0043497 regulation of protein heterodimerization activity	1.962e-2
98	GO:0045055 regulated exocytosis	1.962e-2
98	GO:1900119 positive regulation of execution phase of apoptosis	1.962e-2
98	GO:2000144 positive regulation of DNA-templated transcription, initiation	1.962e-2
98	GO:0006942 regulation of striated muscle contraction	1.962e-2
98	GO:0007512 adult heart development	1.962e-2
98	GO:0000185 activation of MAPKKK activity	1.962e-2
98	GO:0032000 positive regulation of fatty acid beta-oxidation	1.962e-2
98	GO:0008299 isoprenoid biosynthetic process	1.962e-2
109	GO:0042347 negative regulation of NF-kappaB import into nucleus	2.286e-2
109	GO:0045663 positive regulation of myoblast differentiation	2.286e-2
109	GO:2000773 negative regulation of cellular senescence	2.286e-2
109	GO:2000147 positive regulation of cell motility	2.286e-2
109	GO:0007154 cell communication	2.286e-2
109	GO:0033627 cell adhesion mediated by integrin	2.286e-2
109	GO:0010460 positive regulation of heart rate	2.286e-2
109	GO:0014912 negative regulation of smooth muscle cell migration	2.286e-2
117	GO:0007267 cell-cell signaling	2.452e-2
118	GO:0070206 protein trimerization	2.608e-2
118	GO:0055119 relaxation of cardiac muscle	2.608e-2
118	GO:0002244 hematopoietic progenitor cell differentiation	2.608e-2
118	GO:0032469 endoplasmic reticulum calcium ion homeostasis	2.608e-2
118	GO:0030195 negative regulation of blood coagulation	2.608e-2
118	GO:0010744 positive regulation of macrophage derived foam cell differentiation	2.608e-2
124	GO:0042733 embryonic digit morphogenesis	2.929e-2
124	GO:0043206 extracellular fibril organization	2.929e-2
124	GO:2000778 positive regulation of interleukin-6 secretion	2.929e-2
124	GO:0002040 sprouting angiogenesis	2.929e-2
128	GO:0009653 anatomical structure morphogenesis	3.001e-2
129	GO:0006936 muscle contraction	3.137e-2
130	GO:0043588 skin development	3.250e-2
130	GO:1900745 positive regulation of p38MAPK cascade	3.250e-2
130	GO:0006941 striated muscle contraction	3.250e-2
133	GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator	3.569e-2
133	GO:2000679 positive regulation of transcription regulatory region DNA binding	3.569e-2
133	GO:0002042 cell migration involved in sprouting angiogenesis	3.569e-2
136	GO:0042981 regulation of apoptotic process	3.853e-2
137	GO:0042476 odontogenesis	3.887e-2
137	GO:0060021 palate development	3.887e-2
137	GO:0007263 nitric oxide mediated signal transduction	3.887e-2
137	GO:0001935 endothelial cell proliferation	3.887e-2
137	GO:0001954 positive regulation of cell-matrix adhesion	3.887e-2
137	GO:0007568 aging	3.887e-2
143	GO:0046034 ATP metabolic process	4.204e-2
143	GO:0045648 positive regulation of erythrocyte differentiation	4.204e-2
143	GO:0045444 fat cell differentiation	4.204e-2
143	GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules	4.204e-2
143	GO:0031954 positive regulation of protein autophosphorylation	4.204e-2
143	GO:0032270 positive regulation of cellular protein metabolic process	4.204e-2
143	GO:0032924 activin receptor signaling pathway	4.204e-2
150	GO:0045861 negative regulation of proteolysis	4.520e-2
150	GO:0042326 negative regulation of phosphorylation	4.520e-2
150	GO:0050715 positive regulation of cytokine secretion	4.520e-2
150	GO:0001503 ossification	4.520e-2
154	GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator	4.835e-2
154	GO:0048662 negative regulation of smooth muscle cell proliferation	4.835e-2

Rank	DO ID and Name	p-value
1	DOID:11984 hypertrophic cardiomyopathy	5.186e-5
2	DOID:423 myopathy	1.946e-4
3	DOID:3191 nemaline myopathy	2.223e-4
3	DOID:11986 familial hypertrophic cardiomyopathy	2.223e-4
5	DOID:2627 glioma	5.646e-4
6	DOID:4015 spindle cell carcinoma	5.773e-4
7	DOID:114 heart disease	6.976e-4
8	DOID:162 cancer	7.234e-4
9	DOID:6000 heart failure	7.427e-4
10	DOID:289 endometriosis	1.604e-3
11	DOID:10591 pre-eclampsia	1.803e-3
12	DOID:5844 myocardial infarction	2.257e-3
13	DOID:3459 breast carcinoma	2.292e-3
14	DOID:684 hepatocellular carcinoma	2.358e-3
15	DOID:225 syndrome	2.687e-3
16	DOID:12557 Duane retraction syndrome	3.297e-3
16	DOID:11328 schizophreniform disease	3.297e-3
18	DOID:3068 glioblastoma	3.549e-3
19	DOID:5419 schizophrenia	4.784e-3
20	DOID:3770 pulmonary fibrosis	6.182e-3
21	DOID:305 carcinoma	6.562e-3
22	DOID:11782 astigmatism	6.584e-3
22	DOID:12929 endocardial fibroelastosis	6.584e-3
22	DOID:2734 keratosis follicularis	6.584e-3
22	DOID:14768 Saethre-Chotzen syndrome	6.584e-3
26	DOID:1749 squamous cell carcinoma	9.043e-3
27	DOID:11665 trisomy 13	9.860e-3
27	DOID:10376 amblyopia	9.860e-3
27	DOID:2373 hereditary elliptocytosis	9.860e-3
27	DOID:14748 Sotos syndrome	9.860e-3
31	DOID:10652 Alzheimer's disease	9.906e-3
32	DOID:10763 hypertension	1.161e-2
33	DOID:4959 epidermolysis bullosa dystrophica	1.313e-2
34	DOID:4241 malignant neoplasm of breast	1.333e-2
35	DOID:3526 cerebral infarction	1.420e-2
36	DOID:332 amyotrophic lateral sclerosis	1.433e-2
37	DOID:3393 coronary heart disease	1.613e-2
38	DOID:3559 pseudomyxoma peritonei	1.638e-2
38	DOID:1085 trisomy 18	1.638e-2
40	DOID:3371 chondrosarcoma	1.675e-2
41	DOID:9074 systemic lupus erythematosus	1.738e-2
42	DOID:0050156 idiopathic pulmonary fibrosis	1.948e-2
43	DOID:893 hepatolenticular degeneration	1.962e-2
43	DOID:397 restrictive cardiomyopathy	1.962e-2
43	DOID:13088 periventricular leukomalacia	1.962e-2
46	DOID:2985 chronic rejection of renal transplant	2.043e-2
47	DOID:10871 age related macular degeneration	2.120e-2
47	DOID:10283 malignant neoplasm of prostate	2.120e-2
49	DOID:5304 ovarian clear cell adenocarcinoma	2.286e-2
49	DOID:540 strabismus	2.286e-2
49	DOID:6340 unipolar depression	2.286e-2
49	DOID:5828 endometrioid ovary carcinoma	2.286e-2
49	DOID:1231 chronic schizophrenia	2.286e-2
49	DOID:182 calcinosis	2.286e-2
55	DOID:4448 macular degeneration	2.298e-2
56	DOID:1115 sarcoma	2.419e-2
57	DOID:1936 atherosclerosis	2.582e-2
58	DOID:2693 fibroadenoma	2.608e-2
58	DOID:1618 fibroadenoma of breast	2.608e-2
60	DOID:9884 muscular dystrophy	2.802e-2
61	DOID:1909 melanoma	2.904e-2
62	DOID:4233 clear cell sarcoma	2.929e-2
62	DOID:11720 distal muscular dystrophy	2.929e-2
62	DOID:12895 keratoconjunctivitis sicca	2.929e-2
62	DOID:10873 Kuhnt-Junius degeneration	2.929e-2
62	DOID:2340 craniosynostosis	2.929e-2
67	DOID:3007 ductal carcinoma	3.137e-2
68	DOID:3347 osteosarcoma	3.328e-2
69	DOID:8857 lupus erythematosus	3.488e-2
70	DOID:9408 acute myocardial infarction	3.560e-2
71	DOID:3429 inclusion body myositis	3.569e-2
72	DOID:12930 dilated cardiomyopathy	3.779e-2
73	DOID:848 arthritis	3.791e-2
74	DOID:9169 Wiskott-Aldrich syndrome	3.887e-2
74	DOID:13359 Ehlers-Danlos syndrome	3.887e-2
76	DOID:9164 achalasia	4.204e-2
76	DOID:4468 clear cell adenocarcinoma	4.204e-2
78	DOID:11426 ovarian endometriosis	4.835e-2
78	DOID:11383 cryptorchidism	4.835e-2
78	DOID:3194 nerve sheath tumors	4.835e-2
78	DOID:3457 lobular carcinoma	4.835e-2

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MeSH
excl. Neoplasms

MeSH
incl. Neoplasms

Rank	MeSH heading	links	Score
1	Quadriceps Muscle	12	22.91	View
2	Fibroblasts	14	22.50	View
2	Mesoderm	14	22.50	View
4	Epithelial Cells	8	12.83	View
5	Indenes	5	9.47	View
6	Kupffer Cells	2	4.70	View
6	Liver	2	4.70	View
6	Hepatocytes	2	4.70	View
6	Hepatic Stellate Cells	2	4.70	View
10	Ascites	2	3.46	View
10	Peritoneal Cavity	2	3.46	View
10	T-Lymphocytes, Cytotoxic	2	3.46	View
13	Formaldehyde	3	3.36	View
13	Nasal Mucosa	3	3.36	View
15	Chick Embryo	2	3.03	View
15	Neovascularization, Pathologic	2	3.03	View
15	Placenta	2	3.03	View
15	Pre-Eclampsia	2	3.03	View
15	Trophoblasts	2	3.03	View
20	Neoplastic Stem Cells	1	2.87	View
21	Intestines	1	1.44	View
22	Coronary Vessels	1	1.40	View
22	Osteoblasts	1	1.40	View
22	Phosphates	1	1.40	View
22	Chondrocytes	1	1.40	View
22	Myocytes, Smooth Muscle	1	1.40	View
27	Muscle Fibers, Skeletal	1	1.02	View